Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases

Louise A. Mesentier-Louro, Camila Zaverucha-Do-Valle, Paulo H. Rosado-De-Castro, Almir J. Silva, Pedro M. Pimentel-Coelho, Rosalia Mendez-Otero, Marcelo F. Santiago

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Following optic nerve injury associated with acute or progressive diseases, retinal ganglion cells (RGCs) of adult mammals degenerate and undergo apoptosis. These diseases have limited therapeutic options, due to the low inherent capacity of RGCs to regenerate and due to the inhibitory milieu of the central nervous system. Among the numerous treatment approaches investigated to stimulate neuronal survival and axonal extension, cell transplantation emerges as a promising option. This review focuses on cell therapies with bone marrow mononuclear cells and bone marrow-derived mesenchymal stem cells, which have shown positive therapeutic effects in animal models of optic neuropathies. Different aspects of available preclinical studies are analyzed, including cell distribution, potential doses, routes of administration, and mechanisms of action. Finally, published and ongoing clinical trials are summarized.

Original languageEnglish
Article number5078619
JournalStem Cells International
Volume2016
DOIs
StatePublished - 2016
Externally publishedYes

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