Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Tyree D. Williams, Talia Adler, Lindsey Smokoff, Anmoldeep Kaur, Benjamin Rodriguez, Kavita Jyoti Prakash, Edib Redzematovic, Turner S. Baker, Benjamin I. Rapoport, Edward S. Yoon, Douglas P. Beall, Jonathan S. Dordick, Reade A. De Leacy

Research output: Contribution to journalReview articlepeer-review


Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a minimally invasive surgical technique, is widely used to stabilize fractures and restore vertebral height. Acrylic-based cements and calcium phosphate cements are currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone cements and calcium phosphate cements have been associated with various intraoperative and postoperative incidents impacting VCF treatment. Over the past decade, discoveries in the field of biomedical engineering and material science have shown advance-ments toward addressing these limitations. This narrative review aims to assess the potential pitfalls and barriers of the various types of bone cements.

Original languageEnglish
Pages (from-to)1029-1040
Number of pages12
JournalJournal of Pain Research
StatePublished - 2024


  • bone cement
  • kyphoplasty
  • osteoporosis
  • vertebral augmentation
  • vertebral compression fractures
  • vertebroplasty


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