TY - JOUR
T1 - Bone, Brain, Heart study protocol
T2 - A resilient nested, tripartite prospective cohort study of the role of estrogen depletion on HIV pathology
AU - Mehta, C. Christina
AU - Hagen, Kimberly S.
AU - Rubtsova, Anna A.
AU - Lahiri, Cecile D.
AU - Michopoulos, Vasiliki
AU - Moran, Caitlin A.
AU - Haddad, Lisa B.
AU - Titanji, Kehmia
AU - Collins, Lauren F.
AU - Quyyumi, Arshed A.
AU - Neigh, Gretchen
AU - Shaw, Leslee J.
AU - Weitzmann, M. Neale
AU - Waller, Lance
AU - Ofotokun, Ighovwerha
N1 - Publisher Copyright:
Copyright: © 2022 Christina Mehta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/8
Y1 - 2022/8
N2 - Purpose We describe the rationale for and design of an innovative, nested, tripartite prospective observational cohort study examining whether relative estrogen insufficiency-induced inflammation amplifies HIV-induced inflammation to cause end organ damage and worsen age-related co-morbidities affecting the neuro-hypothalamic-pituitary-adrenal axis (Brain), skeletal (Bone), and cardiovascular (Heart/vessels) organ systems (BBH Study). Methods The BBH parent study is the Multicenter AIDS Cohort/Women's Interagency HIV Study Combined Cohort Study (MWCCS) with participants drawn from the Atlanta MWCCS site. BBH will enroll a single cohort of n = 120 women living with HIV and n = 60 HIV-negative women, equally distributed by menopausal status. The innovative multipart nested study design of BBH, which draws on data collected by the parent study, efficiently leverages resources for maximum research impact and requires extensive oversight and management in addition to careful implementation. The presence of strong infrastructure minimized BBH study disruptions due to changes in the parent study and the COVID-19 pandemic. Conclusion BBH is poised to provide insight into sex and HIV associations with the neuro-hypothalamicpituitary-adrenal axis, skeletal, and cardiovascular systems despite several major, unexpected challenges.
AB - Purpose We describe the rationale for and design of an innovative, nested, tripartite prospective observational cohort study examining whether relative estrogen insufficiency-induced inflammation amplifies HIV-induced inflammation to cause end organ damage and worsen age-related co-morbidities affecting the neuro-hypothalamic-pituitary-adrenal axis (Brain), skeletal (Bone), and cardiovascular (Heart/vessels) organ systems (BBH Study). Methods The BBH parent study is the Multicenter AIDS Cohort/Women's Interagency HIV Study Combined Cohort Study (MWCCS) with participants drawn from the Atlanta MWCCS site. BBH will enroll a single cohort of n = 120 women living with HIV and n = 60 HIV-negative women, equally distributed by menopausal status. The innovative multipart nested study design of BBH, which draws on data collected by the parent study, efficiently leverages resources for maximum research impact and requires extensive oversight and management in addition to careful implementation. The presence of strong infrastructure minimized BBH study disruptions due to changes in the parent study and the COVID-19 pandemic. Conclusion BBH is poised to provide insight into sex and HIV associations with the neuro-hypothalamicpituitary-adrenal axis, skeletal, and cardiovascular systems despite several major, unexpected challenges.
UR - http://www.scopus.com/inward/record.url?scp=85135591825&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0272608
DO - 10.1371/journal.pone.0272608
M3 - Article
C2 - 35921353
AN - SCOPUS:85135591825
SN - 1932-6203
VL - 17
JO - PLoS ONE
JF - PLoS ONE
IS - 8 August
M1 - e0272608
ER -