BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects across Class A GPCRs

Keyphrases

• Ligand Discovery 100%
• Bioactivity 100%
• G Protein-coupled Receptor 100%
• Transformer 100%
• Mutational Effects 100%
• Ligand-receptor Binding 25%
• Structural Information 12%
• Drug Discovery 12%
• Receptor Subtypes 12%
• Structure-based Approaches 12%
• Deep Learning Framework 12%
• Performance Prediction 12%
• Web Interface 12%
• Ligand Structure 12%
• Transformer-based 12%
• Ligand-based 12%
• Transfer Learning 12%
• Sequence of Functions 12%
• Neural Network Classifier 12%
• Advanced Strategies 12%
• Dense Neural Network 12%
• Protein Language Model 12%

Biochemistry, Genetics and Molecular Biology

• G Protein Coupled Receptor 100%
• Biological Activity 100%
• Transfer of Learning 8%
• Drug Development 8%
• Protein Language Model 8%

Pharmacology, Toxicology and Pharmaceutical Science

• G Protein Coupled Receptor 100%
• Receptor 33%
• Drug Discovery 8%
• Receptor Subtype 8%