TY - JOUR
T1 - Body-wide multi-omic counteraction of aging with GLP-1R agonism Erratum to
T2 - Body-wide multi-omic counteraction of aging with GLP-1R agonism (Cell Metabolism, (2025), 37, 12, (2362-2380.e8), (S1550413125004747), (10.1016/j.cmet.2025.10.014))
AU - Huang, Junzhe
AU - Kwok, Andrew J.
AU - Yan Li, Jason Chak
AU - Hin Chiu, Clement Lek
AU - Ip, Bonaventure Y.
AU - Tung, Lok Yi
AU - Chan, Roy C.H.
AU - Chan, Danny C.W.
AU - Wang, Ziyu
AU - Zheng, Xianyi
AU - Chow, Hoi Tung
AU - Lo, Michelle P.S.
AU - Li, Zhongqi
AU - Lin, Nenghan
AU - Wang, Manyu
AU - Yan, Leo Y.C.
AU - Wu, William K.K.
AU - Hei-Man Chow, Kim
AU - Lin, Wei Jye
AU - Tang, Yamei
AU - Zhang, Yun
AU - Song, Weihong
AU - Wai-Lung Ng, Billy
AU - Wong, Sunny H.
AU - Leung, Thomas W.
AU - Mok, Vincent C.T.
AU - Ko, Ho
N1 - Publisher Copyright:
© 2026 The Author(s).
PY - 2026/5/5
Y1 - 2026/5/5
N2 - (Cell Metabolism 37, 2362–2380.e1–e8; December 2, 2025) Following publication, Steve Horvath and colleagues at the Clock Foundation alerted us to a platemap error in the DNA methylation (DNAm) data. Our investigation pinpointed the potential source of this error. We provided samples on 96-well plates in a row-wise orientation instead of the column-wise orientation specified in the Clock Foundation’s protocol. Subsequently, incorrect assignment of metadata for 36 samples (out of 459) that contributed data to the paper likely occurred during the transposition and rearrangement of a subset of samples on two incompletely filled plates prior to the assay. Working with Clock Foundation colleagues, we have corrected the metadata for 33 samples and discarded 3 samples for which we could not retrieve the metadata with total certainty. This error impacted DNAm data for the following tissues:(1)In the long-term treatment cohort, hypothalamus, liver, and circulating white blood cells (WBCs), which required changes to Figures 4, S3C, S3D, S5A, and S5B.(2)In the short-term treatment cohort, heart, which required changes to Figures 5H, 5I, 6C, 6F, S5C, S8F, S9C, S9D, and S10B. In the long-term treatment cohort, hypothalamus, liver, and circulating white blood cells (WBCs), which required changes to Figures 4, S3C, S3D, S5A, and S5B. In the short-term treatment cohort, heart, which required changes to Figures 5H, 5I, 6C, 6F, S5C, S8F, S9C, S9D, and S10B. We have performed a complete re-analysis of the DNAm data for the affected tissues and updated all relevant figures. We have also updated two sentences in the main text based on the updated plots and analyses. This correction does not alter any other conclusions of the paper. The corresponding source data file and deposited data have also been updated. We thank Steve Horvath and Clock Foundation colleagues for their assistance in resolving this issue and sincerely apologize for any confusion or inconvenience this error may have caused.
AB - (Cell Metabolism 37, 2362–2380.e1–e8; December 2, 2025) Following publication, Steve Horvath and colleagues at the Clock Foundation alerted us to a platemap error in the DNA methylation (DNAm) data. Our investigation pinpointed the potential source of this error. We provided samples on 96-well plates in a row-wise orientation instead of the column-wise orientation specified in the Clock Foundation’s protocol. Subsequently, incorrect assignment of metadata for 36 samples (out of 459) that contributed data to the paper likely occurred during the transposition and rearrangement of a subset of samples on two incompletely filled plates prior to the assay. Working with Clock Foundation colleagues, we have corrected the metadata for 33 samples and discarded 3 samples for which we could not retrieve the metadata with total certainty. This error impacted DNAm data for the following tissues:(1)In the long-term treatment cohort, hypothalamus, liver, and circulating white blood cells (WBCs), which required changes to Figures 4, S3C, S3D, S5A, and S5B.(2)In the short-term treatment cohort, heart, which required changes to Figures 5H, 5I, 6C, 6F, S5C, S8F, S9C, S9D, and S10B. In the long-term treatment cohort, hypothalamus, liver, and circulating white blood cells (WBCs), which required changes to Figures 4, S3C, S3D, S5A, and S5B. In the short-term treatment cohort, heart, which required changes to Figures 5H, 5I, 6C, 6F, S5C, S8F, S9C, S9D, and S10B. We have performed a complete re-analysis of the DNAm data for the affected tissues and updated all relevant figures. We have also updated two sentences in the main text based on the updated plots and analyses. This correction does not alter any other conclusions of the paper. The corresponding source data file and deposited data have also been updated. We thank Steve Horvath and Clock Foundation colleagues for their assistance in resolving this issue and sincerely apologize for any confusion or inconvenience this error may have caused.
UR - https://www.scopus.com/pages/publications/105034772985
U2 - 10.1016/j.cmet.2026.03.016
DO - 10.1016/j.cmet.2026.03.016
M3 - Comment/debate
AN - SCOPUS:105034772985
SN - 1550-4131
VL - 38
SP - 1034
EP - 1047
JO - Cell Metabolism
JF - Cell Metabolism
IS - 5
ER -