Body weight gain after food deprivation depends on baseline plasma leptin levels in rats

A. Buison, M. Pellizzon, S. Fried, K. L.C. Jen

Research output: Contribution to journalArticlepeer-review

Abstract

Leptin (LP), the ob gene product, is involved in body weight regulation and has been shown to be related to obesity in both animals and humans. We examined the effect of 20% BW loss on plasma LP levels, BW gain and body composition in rats. Sixteen female Wistar rats were divided into 2 groups: 1) DEP (n=9) rats were food deprived (rodent diet) for 76 hours and then were re-fed ad lib for the rest of the study; 2) CON (n=7) rats were fed ad lib throughout the entire study. All rats had water ad lib. Rats were sacrificed after 3 wks. It was observed that DEP rats had different LP responses to BW loss. Thus, we subdivided the DEP rats into 2 groups: 1) DEP-UP (n=4) had low baseline LP and increased LP levels after BW loss and 2) DEP-DN (n=5) had high baseline LP and decreased LP levels after BW loss. DEP-DN rats lost significantly more BW after food deprivation (55.2±3.7g vs. 37.5±7.5g, p<0.05) and regained significantly less weight than that of the DEP-UP rats (1.8±7.6g vs. 30.3±4.6g, p<0.01). DEP rats had significantly higher subcutaneous and total fat weights compared to CON rats (p<0.05). Thus, those with high LP levels can maintain a constant BW better than those with low LP. Over time, those with low LP may gain more BW than that was lost and may be more prone to obesity.

Original languageEnglish
Pages (from-to)A230
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

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