Body Cavity - Based Malignant Lymphoma Containing Kaposi Sarcoma - Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma

James A. Strauchen, A. Daniel Hauser, David Burstein, Ricardo Jimenez, Patrick S. Moore, Yuan Chang

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Background: The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established. Objective: To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma. Design: Case study. Setting: Academic medical center. Patient: A 94-year-old man with lymphomatous ascites. Measurements: Polymerase chain reaction (PCR) and Southern blot DNA analysis. Results: The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpes-virus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation. Conclusions: Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.

Original languageEnglish
Pages (from-to)822-825
Number of pages4
JournalAnnals of Internal Medicine
Volume125
Issue number10
DOIs
StatePublished - 15 Nov 1996
Externally publishedYes

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