TY - JOUR
T1 - Body Cavity - Based Malignant Lymphoma Containing Kaposi Sarcoma - Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma
AU - Strauchen, James A.
AU - Hauser, A. Daniel
AU - Burstein, David
AU - Jimenez, Ricardo
AU - Moore, Patrick S.
AU - Chang, Yuan
PY - 1996/11/15
Y1 - 1996/11/15
N2 - Background: The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established. Objective: To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma. Design: Case study. Setting: Academic medical center. Patient: A 94-year-old man with lymphomatous ascites. Measurements: Polymerase chain reaction (PCR) and Southern blot DNA analysis. Results: The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpes-virus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation. Conclusions: Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.
AB - Background: The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established. Objective: To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma. Design: Case study. Setting: Academic medical center. Patient: A 94-year-old man with lymphomatous ascites. Measurements: Polymerase chain reaction (PCR) and Southern blot DNA analysis. Results: The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpes-virus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation. Conclusions: Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.
UR - http://www.scopus.com/inward/record.url?scp=0030588580&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-125-10-199611150-00006
DO - 10.7326/0003-4819-125-10-199611150-00006
M3 - Article
C2 - 8928989
AN - SCOPUS:0030588580
SN - 0003-4819
VL - 125
SP - 822
EP - 825
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 10
ER -