BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

Jong Sun Kang, Philip J. Mulieri, Yulan Hu, Lavinia Taliana, Robert S. Krauss

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117 Scopus citations


CDO is a cell surface receptor-like protein that positively regulates myogenic differentiation. Reported here is the identification of BOC, which, with CDO, defines a newly recognized subfamily within the immunoglobulin superfamily, cdo and boc are co-expressed in muscle precursors in the developing mouse embryo. Like CDO, BOC accelerates differentiation of cultured myoblast cell lines and participates in a positive feedback loop with the myogenic transcription factor, MyoD. CDO and BOC form complexes in a cis fashion via association of both their ectodomains and their intracellular domains. A soluble fusion protein that contains the entire BOC ectodomain functions similarly to full-length BOC to promote myogenic differentiation, indicating that the intracellular region is dispensable for its activity in this system. Furthermore, a dominant-negative form of CDO inhibits the pro-myogenic effects of soluble BOC, suggesting that BOC is dependent on CDO for its activity. CDO and BOC are proposed to be components of a receptor complex that mediates some of the cell-cell interactions between muscle precursors that are required for myogenesis.

Original languageEnglish
Pages (from-to)114-124
Number of pages11
JournalEMBO Journal
Issue number1-2
StatePublished - 15 Jan 2002


  • Cell differentiation
  • Ig superfamily
  • MyoD
  • Myogenesis


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