BMP-2@PNH-TA hydrogel with osteogenic and antibacterial properties for integrated photothermal therapy

Jiwei Sun, Haojie Wei, Haoqi Lei, Tiantian Chen, Keqi Wo, Junyuan Zhang, Guangxia Feng, Jiechen Wang, Yifan Zhang, Yifan Wang, Jinyu Wang, Zhen Zhang, Yingying Chu, Lihong Fan, Jian Zhou, Lili Chen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Progress toward developing next-generation biomaterials applied in complex bone defect is expected to effectively integrate osteogenic and anti-bacteria capability. However, current biomaterials often achieve the two functions separately. Inspired by photothermal effect, exogenous light-induced thermal variations can efficiently facilitate bone regeneration and bacteria eradication. Here, a bioactive hydrogel BMP-2@PNH-TA with simultaneously osteogenic and anti-bacterial capacities is presented, which is based on the near infrared (NIR) induced photothermal effect to perform integrated photothermal therapy (PTT). In detail, photothermal effect and photothermal-controlled release of osteogenic and anti-bacterial factors through sponge-like effect could exert integrated influence on bone regeneration under complex situation. The composite hydrogel can mediate pro-osteogenesis under mild temperature and controlled release of BMP-2 and tannin in response to NIR stimulation with low power, while efficiently eradicate bacteria via controlled release of O-HACC and thermal effect with high power. The customized PTT strategy significantly shortened the duration time of bone regeneration up to almost 50% in rat cranial bone defect. It is anticipated that the concept of integrated PTT for bone regeneration will cast new insights into developing high-performance therapeutic strategy with combined biological functions.

Original languageEnglish
Article number111954
JournalMaterials and Design
Volume230
DOIs
StatePublished - Jun 2023
Externally publishedYes

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