TY - JOUR
T1 - Blood manganese levels during pregnancy and postpartum depression
T2 - A cohort study among women in Mexico
AU - McRae, Nia
AU - Bello, Ghalib
AU - Svensson, Katherine
AU - Solano-González, Maritsa
AU - Wright, Rosalind J.
AU - Niedzwiecki, Megan M.
AU - Calapiz, Mariana Torres
AU - Amarasiriwardena, Chitra
AU - Schnaas, Lourdes
AU - Tamayo-Ortiz, Marcela
AU - Téllez-Rojo, Martha M.
AU - Wright, Robert O.
N1 - Funding Information:
The Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) project was funded by the following National Institute of Environmental Health Sciences (NIEHS) grants: R01ES013744; R01ES014930; R01ES021357; R24ES028522; P30ES023515. PROGRESS received support and partial funding from the National Institute of Public Health (INSP)/Ministry of Health of Mexico. Support during analyses and manuscript preparation was provided through a grant from the National Heart Lung and Blood Institute (NHLBI) through the Short-term Research Training Program for Minority Students (R25HL108857). We are grateful to the PROGRESS staff, participants and their families. We would like to thank the American British Cowdray (ABC) Hospital and National Institute of Perinatology in Mexico City, Mexico, for providing facilities for this research.
Funding Information:
The Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) project was funded by the following National Institute of Environmental Health Sciences (NIEHS) grants: R01ES013744 ; R01ES014930 ; R01ES021357 ; R24ES028522 ; P30ES023515 . PROGRESS received support and partial funding from the National Institute of Public Health (INSP)/Ministry of Health of Mexico . Support during analyses and manuscript preparation was provided through a grant from the National Heart Lung and Blood Institute (NHLBI) through the Short-term Research Training Program for Minority Students ( R25HL108857 ). We are grateful to the PROGRESS staff, participants and their families. We would like to thank the American British Cowdray (ABC) Hospital and National Institute of Perinatology in Mexico City, Mexico, for providing facilities for this research.
Publisher Copyright:
© 2019 The Authors
PY - 2020/1
Y1 - 2020/1
N2 - Background: Occupational studies have shown an association between elevated Mn exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due to mobilization from tissues, suggesting it could contribute to pregnancy and postpartum depressive symptoms. Objectives: To assess the association between BMn levels during pregnancy and postpartum depression (PPD), creating opportunities for possible future interventions. Methods: We studied 561 women from the reproductive longitudinal Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) cohort in Mexico City. BMn was measured at the 2nd and 3rd trimesters, as well as delivery. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD symptoms at 12-months postpartum. We used a generalized linear model assuming a Poisson distribution to assess the association between BMn levels and PPD, with adjustments for age, stress and depressive symptoms during pregnancy, education, socioeconomic status, and contemporaneous blood lead levels. Results: The mean ± standard deviation (SD) EPDS score at 12-months postpartum was 6.51 ± 5.65, and 17.11% of women met the criteria for possible PPD (score ≥ 13). In adjusted models, BMn during the 3rd trimester (β: 0.13, 95% CI: 0.04-0.21) and BMn levels averaged at the 2nd and 3rd trimester (β: 0.14, 95% CI: 0.02-0.26) had a positive association with EPDS scores at 12 months postpartum. BMn at the 2nd trimester (β: 0.07, 95% CI: -0.09-0.22) and delivery (β: 0.03, 95% CI: -0.04-0.10) had a non-significant positive association with EPDS scores at 12-months postpartum. Stress and depressive symptoms during pregnancy was associated with higher EPDS scores at 12-months postpartum in all of the adjusted models but were only significant when either BMn during 3rd trimester or BMn averaged across 2nd and 3rd trimester was assessed as the exposure. Discussion: Our results demonstrate that elevated BMn levels during pregnancy predict PPD symptoms and could be a potential pathway for intervention and prevention of PPD.
AB - Background: Occupational studies have shown an association between elevated Mn exposure and depressive symptoms. Blood Mn (BMn) naturally rises during pregnancy due to mobilization from tissues, suggesting it could contribute to pregnancy and postpartum depressive symptoms. Objectives: To assess the association between BMn levels during pregnancy and postpartum depression (PPD), creating opportunities for possible future interventions. Methods: We studied 561 women from the reproductive longitudinal Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) cohort in Mexico City. BMn was measured at the 2nd and 3rd trimesters, as well as delivery. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD symptoms at 12-months postpartum. We used a generalized linear model assuming a Poisson distribution to assess the association between BMn levels and PPD, with adjustments for age, stress and depressive symptoms during pregnancy, education, socioeconomic status, and contemporaneous blood lead levels. Results: The mean ± standard deviation (SD) EPDS score at 12-months postpartum was 6.51 ± 5.65, and 17.11% of women met the criteria for possible PPD (score ≥ 13). In adjusted models, BMn during the 3rd trimester (β: 0.13, 95% CI: 0.04-0.21) and BMn levels averaged at the 2nd and 3rd trimester (β: 0.14, 95% CI: 0.02-0.26) had a positive association with EPDS scores at 12 months postpartum. BMn at the 2nd trimester (β: 0.07, 95% CI: -0.09-0.22) and delivery (β: 0.03, 95% CI: -0.04-0.10) had a non-significant positive association with EPDS scores at 12-months postpartum. Stress and depressive symptoms during pregnancy was associated with higher EPDS scores at 12-months postpartum in all of the adjusted models but were only significant when either BMn during 3rd trimester or BMn averaged across 2nd and 3rd trimester was assessed as the exposure. Discussion: Our results demonstrate that elevated BMn levels during pregnancy predict PPD symptoms and could be a potential pathway for intervention and prevention of PPD.
KW - Cohort study
KW - Manganese
KW - Mexico
KW - Postpartum depression
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85075580594&partnerID=8YFLogxK
U2 - 10.1016/j.neuro.2019.11.005
DO - 10.1016/j.neuro.2019.11.005
M3 - Article
C2 - 31730893
AN - SCOPUS:85075580594
SN - 0161-813X
VL - 76
SP - 183
EP - 190
JO - NeuroToxicology
JF - NeuroToxicology
ER -