Blood lymphocytes in infectious mononucleosis share the following characteristics with activated T cells: Natural attachment, stable E rosetting and glucocorticoid sensitivity

U. Galili, J. Seeley, E. Svedmyr, E. Klein, G. Klein, O. Weiland

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Blood lymphocytes of infectious mononucleosis (IM) patients, unlike those obtained from healthy individuals, exhibit the following characteristics of activated T cells: (I) 'stable' E rosette formation; (2) natural attachment to various human normal and malignant cells; (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the IM T cells attach in vitro to all the human cells tested, they kill only the EBV genome carrying targets. The possibility is discussed that some of the activated T cells in IM result from a non-specific activation elicited by the T cells responding specifically to the EBV associated antigens.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Clinical and Laboratory Immunology
Volume3
Issue number3
StatePublished - 1980

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