TY - JOUR
T1 - Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children
AU - Nie, Linda H.
AU - Wright, Robert O.
AU - Bellinger, David C.
AU - Hussain, Javed
AU - Amarasiriwardena, Chitra
AU - Chettle, David R.
AU - Pejović-Milić, Ana
AU - Woolf, Alan
AU - Shannon, Michael
N1 - Funding Information:
The research described in this paper was supported primarily by NIEHS R01-ES013744 and RO1 ES014930. This work was also supported in part by a grant from the Agency for Toxic Substances and Disease Registry (ATSDR) with additional support from the U.S. Environmental Protection Agency (EPA), administered through the Association of Occupational and Environmental Clinics Association (AOEC), Washington D.C. Test subjects were evaluated for bone lead levels, blood lead levels, and neurodevelopmental performance in the Clinical Translational Science Award (CTSA) program of the Children’s Hospital Boston. The authors would like to thank the administrative and clinical staff at the CTSA for their support. The authors would also like to thank Lesley Egden at McMaster University for her assistance with the project. The contents of this manuscript are solely the responsibilityoftheauthorsanddonotnecessarilyrepresent theofficialviewsoftheNIEHS,ATSDR,orEPA.Theauthors declare they have no competing financial interests.
PY - 2011/9
Y1 - 2011/9
N2 - Objective: To find the best lead exposure assessment marker for children. Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
AB - Objective: To find the best lead exposure assessment marker for children. Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
KW - Heavy metal toxicity
KW - environmental pollution/ecotoxicology
KW - neurological disease
UR - http://www.scopus.com/inward/record.url?scp=80051983425&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2011.604133
DO - 10.3109/1354750X.2011.604133
M3 - Article
C2 - 21827276
AN - SCOPUS:80051983425
SN - 1354-750X
VL - 16
SP - 517
EP - 524
JO - Biomarkers
JF - Biomarkers
IS - 6
ER -