TY - JOUR
T1 - Blood in a dish
T2 - In vitro synthesis of red blood cells
AU - Migliaccio, Anna Rita
AU - Palis, James
N1 - Funding Information:
This study was supported by a grant from the NY-STAR foundation ( C-06066 ), from Centro Nazionale Sangue, Rome, Italy and by institutional funds from the Mount Sinai School of Medicine and Istituto Superiore Sanità, Italy (ARM) , as well as from NIDDK/NIH and NYSTEM (JP). Drs. Carolyn Whitsett, Giovanni Migliaccio, Samantha England and Ah Ram Kim are gratefully acknowledged for insights and helpful discussions. We thank Scott Peslak with assistance for Fig. 1 .
PY - 2011
Y1 - 2011
N2 - Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the in vitro generation of fully mature red cells. The extensive in vitro expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.
AB - Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the in vitro generation of fully mature red cells. The extensive in vitro expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.
UR - https://www.scopus.com/pages/publications/84859799861
U2 - 10.1016/j.ddmec.2011.10.002
DO - 10.1016/j.ddmec.2011.10.002
M3 - Review article
AN - SCOPUS:84859799861
SN - 1740-6765
VL - 8
SP - e3
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 1-2
ER -