Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

Xin Hua Tian; Feng Wei; Tian Xiao Wang; Dong Wang; Jun Wang; Xiao Ning Lin; Peng Wang; Lei Ren

doi:10.1016/j.matlet.2011.10.042

Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

Xin Hua Tian, Feng Wei, Tian Xiao Wang, Dong Wang, Jun Wang, Xiao Ning Lin, Peng Wang, Lei Ren

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB.

Original language	English
Pages (from-to)	94-96
Number of pages	3
Journal	Materials Letters
Volume	68
DOIs	https://doi.org/10.1016/j.matlet.2011.10.042
State	Published - 1 Feb 2012
Externally published	Yes

Keywords

Biomaterials
Blood-brain barrier
In vivo assay
Nanoparticles
Targeted delivery

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10.1016/j.matlet.2011.10.042

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title = "Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle",

abstract = "Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB.",

keywords = "Biomaterials, Blood-brain barrier, In vivo assay, Nanoparticles, Targeted delivery",

author = "Tian, {Xin Hua} and Feng Wei and Wang, {Tian Xiao} and Dong Wang and Jun Wang and Lin, {Xiao Ning} and Peng Wang and Lei Ren",

note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China ( 30970733 , 81171448 , 81172394 ), and the National Basic Research Program of China ( 2010CB732402 ).",

year = "2012",

month = feb,

day = "1",

doi = "10.1016/j.matlet.2011.10.042",

language = "English",

volume = "68",

pages = "94--96",

journal = "Materials Letters",

issn = "0167-577X",

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TY - JOUR

T1 - Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

AU - Tian, Xin Hua

AU - Wei, Feng

AU - Wang, Tian Xiao

AU - Wang, Dong

AU - Wang, Jun

AU - Lin, Xiao Ning

AU - Wang, Peng

AU - Ren, Lei

N1 - Funding Information: This work was financially supported by the National Natural Science Foundation of China ( 30970733 , 81171448 , 81172394 ), and the National Basic Research Program of China ( 2010CB732402 ).

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB.

AB - Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB.

KW - Biomaterials

KW - Blood-brain barrier

KW - In vivo assay

KW - Nanoparticles

KW - Targeted delivery

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DO - 10.1016/j.matlet.2011.10.042

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SN - 0167-577X

VL - 68

SP - 94

EP - 96

JO - Materials Letters

JF - Materials Letters

ER -

Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

Abstract

Keywords

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