Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

Xin Hua Tian, Feng Wei, Tian Xiao Wang, Dong Wang, Jun Wang, Xiao Ning Lin, Peng Wang, Lei Ren

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalMaterials Letters
Volume68
DOIs
StatePublished - 1 Feb 2012
Externally publishedYes

Keywords

  • Biomaterials
  • Blood-brain barrier
  • In vivo assay
  • Nanoparticles
  • Targeted delivery

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