TY - JOUR
T1 - Bivalirudin in Primary PCI
T2 - Can Its Glory Being Restored?
AU - Li, Yang
AU - Li, Yi
AU - Stone, Gregg W.
AU - Han, Yaling
N1 - Publisher Copyright:
Copyright © 2021 The Chinese Medical Association, published by Wolters Kluwer Health, Inc.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Intravenous anticoagulant therapy is critical to prevent ischemic recurrences and complications without increasing the risk of bleeding in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). It includes the indirect thrombin inhibitor heparins and the direct thrombin inhibitor bivalirudin. However, the ideal anticoagulant for patients undergoing PPCI remains controversial. In this review, we provide an overview of currently available anticoagulant therapies used in STEMI patients undergoing PPCI, including describing the rationale for their use, pivotal clinical trial data, and treatment recommendations of guidelines, providing much-needed clarity to guide the selection of the safest and most effective anticoagulant regimens for PPCI.
AB - Intravenous anticoagulant therapy is critical to prevent ischemic recurrences and complications without increasing the risk of bleeding in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). It includes the indirect thrombin inhibitor heparins and the direct thrombin inhibitor bivalirudin. However, the ideal anticoagulant for patients undergoing PPCI remains controversial. In this review, we provide an overview of currently available anticoagulant therapies used in STEMI patients undergoing PPCI, including describing the rationale for their use, pivotal clinical trial data, and treatment recommendations of guidelines, providing much-needed clarity to guide the selection of the safest and most effective anticoagulant regimens for PPCI.
KW - Bivalirudin
KW - Heparin
KW - Primary percutaneous coronary intervention
KW - ST-segment elevation myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=85142498405&partnerID=8YFLogxK
U2 - 10.1097/CD9.0000000000000016
DO - 10.1097/CD9.0000000000000016
M3 - Article
AN - SCOPUS:85142498405
SN - 2096-952X
VL - 1
SP - 179
EP - 194
JO - Cardiology Discovery
JF - Cardiology Discovery
IS - 3
ER -