Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Eric A. Sobie; Matthew G. Fishler; Leslie Tung

Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Eric A. Sobie, Matthew G. Fishler, Leslie Tung

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

Original language	English
Pages (from-to)	257-258
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	17
Issue number	1
State	Published - 1995
Externally published	Yes
Event	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: 20 Sep 1995 → 23 Sep 1995

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title = "Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model",

abstract = "A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.",

author = "Sobie, {Eric A.} and Fishler, {Matthew G.} and Leslie Tung",

year = "1995",

language = "English",

volume = "17",

pages = "257--258",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

number = "1",

note = "Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) ; Conference date: 20-09-1995 Through 23-09-1995",

}

Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model. / Sobie, Eric A.; Fishler, Matthew G.; Tung, Leslie.
In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 17, No. 1, 1995, p. 257-258.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

AU - Sobie, Eric A.

AU - Fishler, Matthew G.

AU - Tung, Leslie

PY - 1995

Y1 - 1995

N2 - A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

AB - A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

UR - http://www.scopus.com/inward/record.url?scp=0029431225&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0029431225

SN - 0589-1019

VL - 17

SP - 257

EP - 258

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

IS - 1

T2 - Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)

Y2 - 20 September 1995 through 23 September 1995

ER -

Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Abstract

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