Bioptic intraprostatic chronic inflammation predicts adverse pathology at radical prostatectomy in patients with low-grade prostate cancer

Francesca Sanguedolce, Ugo Giovanni Falagario, Pietro Castellan, Michele Di Nauta, Giovanni Silecchia, Salvatore M. Bruno, Davide Russo, Patrick Julien Treacy, Ashutosh K. Tewari, Rodolfo Montironi, Giuseppe Carrieri, Luigi Cormio

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12 Scopus citations

Abstract

Purpose: To determine the potential role of bioptic inflammation (Irani score) in predicting adverse pathology (AP) at radical prostatectomy (RP) in patients with low-grade (ISUP Gleason Group [ISUP GG] 1 and 2) prostate cancer (CaP). Methods: After institutional review board-approval, we identified patients who underwent prostate biopsy, had bioptic Irani score assessment, were diagnosed with low-grade CaP (ISUP GG 1–2, prostate-specific antigen [PSA] <20 ng/ml), and underwent RP. The impact of standard clinicopathological variables and bioptic Irani Score (G = grade and A = aggressiveness) on AP at RP, defined as stage ≥T3 and/or ISUP GG ≥3, was assessed by univariate and multivariate logistic regression analysis. Results: A total of 282 patients were eligible for this study. AP at RP occurred in 37 of 214 (17.3%) patients with ISUP GG 1, and 26 of 68 (38.2%) with ISUP GG 2. At univariate analysis, serum PSA, PSA density, bioptic ISUP GG, number of positive cores, total percentage of core involvement and Irani G score emerged as significant risk factors of AP. At multivariate analysis, however, only PSA density, bioptic ISUP GG, total percentage of core, and Irani G score kept statistical significance. The area under the curve for the resulting model was 0.75. Conclusions: This is the first study demonstrating that low-grade inflammation is associated with a significantly increased risk of AP at RP. These findings would support the concept of prostatic inflammation being inversely correlated with presence and aggressiveness of CaP. Further studies are needed to externally validate the role of this readily available parameter in the decision-making process of patients with low-grade CaP.

Original languageEnglish
Pages (from-to)793.e19-793.e25
JournalUrologic Oncology: Seminars and Original Investigations
Volume38
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Active surveillance
  • Low grade prostate biopsy
  • Prostate cancer
  • Prostatic inflammation
  • Radical prostatectomy
  • Upgrading

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