Bionanoconjugate-based composites for decontamination of nerve agents

Indrakant V. Borkar, Cerasela Zoica Dinu, Guangyu Zhu, Ravi S. Kane, Jonathan S. Dordick

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We have developed enzyme-based composites that rapidly and effectively detoxify simulants of V- and G-type chemical warfare nerve agents. The approach was based on the efficient immobilization of organophosphorus hydrolase onto carbon nanotubes to form active and stable conjugates that were easily entrapped in commercially available paints. The resulting catalytic-based composites showed no enzyme leaching and rendered >99% decontamination of 10 g/m2 paraoxon, a simulant of the V-type nerve agent, in 30 minutes and >95% decontamination of diisopropylfluorophosphate, a simulant of G-type nerve agent, in 45 minutes. The formulations are expected to be environmentally friendly and to offer an easy to use, on demand, decontamination alternative to chemical approaches for sustainable material self-decontamination.

Original languageEnglish
Pages (from-to)1622-1628
Number of pages7
JournalBiotechnology Progress
Volume26
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Carbon nanotubes
  • Chemical decontamination
  • Enzyme-based nanocomposite
  • Organophosphorus hydrolase

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