Biomedical applications of Multi-Functional Silica-Based gold nanoshells

Lissett R. Bickford; Emily S. Day; Ying Hu; Jiantang Sun; Kun Fu; Joseph Chang; Nastassja A. Lewinski; Tse Kuan Yu; Rebekah A. Dreze

doi:10.4032/9789814267588

Biomedical applications of Multi-Functional Silica-Based gold nanoshells

Lissett R. Bickford, Emily S. Day, Ying Hu, Jiantang Sun, Kun Fu, Joseph Chang, Nastassja A. Lewinski, Tse Kuan Yu, Rebekah A. Dreze

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Silica-based gold nanoshells have a unique design resulting in diverse optical properties that can be exploited for a multitude of biomedical applications. By varying the size of the silica core and gold outer shell, these nanoparticles can be fabricated to scatter or absorb light in the near-infrared, where penetration of light through tissue is at a maximum. In this chapter, we discuss the multipurpose utility of these particles as agents in diagnostic imaging, photothermal cancer therapy, laser-tissue welding, drug delivery, and immunoassays. In order to address concerns of using gold nanoshells for in vivo applications, we also summarize previously documented experimental evaluations of gold nanoshell cytotoxicity.

Original language	English
Title of host publication	Handbook of Materials for Nanomedicine
Publisher	Pan Stanford Publishing Pte. Ltd.
Pages	633-662
Number of pages	30
ISBN (Print)	9789814267557
DOIs	https://doi.org/10.4032/9789814267588
State	Published - 1 Sep 2010
Externally published	Yes

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10.4032/9789814267588

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abstract = "Silica-based gold nanoshells have a unique design resulting in diverse optical properties that can be exploited for a multitude of biomedical applications. By varying the size of the silica core and gold outer shell, these nanoparticles can be fabricated to scatter or absorb light in the near-infrared, where penetration of light through tissue is at a maximum. In this chapter, we discuss the multipurpose utility of these particles as agents in diagnostic imaging, photothermal cancer therapy, laser-tissue welding, drug delivery, and immunoassays. In order to address concerns of using gold nanoshells for in vivo applications, we also summarize previously documented experimental evaluations of gold nanoshell cytotoxicity.",

author = "Bickford, {Lissett R.} and Day, {Emily S.} and Ying Hu and Jiantang Sun and Kun Fu and Joseph Chang and Lewinski, {Nastassja A.} and Yu, {Tse Kuan} and Dreze, {Rebekah A.}",

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T1 - Biomedical applications of Multi-Functional Silica-Based gold nanoshells

AU - Bickford, Lissett R.

AU - Day, Emily S.

AU - Hu, Ying

AU - Sun, Jiantang

AU - Fu, Kun

AU - Chang, Joseph

AU - Lewinski, Nastassja A.

AU - Yu, Tse Kuan

AU - Dreze, Rebekah A.

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Silica-based gold nanoshells have a unique design resulting in diverse optical properties that can be exploited for a multitude of biomedical applications. By varying the size of the silica core and gold outer shell, these nanoparticles can be fabricated to scatter or absorb light in the near-infrared, where penetration of light through tissue is at a maximum. In this chapter, we discuss the multipurpose utility of these particles as agents in diagnostic imaging, photothermal cancer therapy, laser-tissue welding, drug delivery, and immunoassays. In order to address concerns of using gold nanoshells for in vivo applications, we also summarize previously documented experimental evaluations of gold nanoshell cytotoxicity.

AB - Silica-based gold nanoshells have a unique design resulting in diverse optical properties that can be exploited for a multitude of biomedical applications. By varying the size of the silica core and gold outer shell, these nanoparticles can be fabricated to scatter or absorb light in the near-infrared, where penetration of light through tissue is at a maximum. In this chapter, we discuss the multipurpose utility of these particles as agents in diagnostic imaging, photothermal cancer therapy, laser-tissue welding, drug delivery, and immunoassays. In order to address concerns of using gold nanoshells for in vivo applications, we also summarize previously documented experimental evaluations of gold nanoshell cytotoxicity.

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BT - Handbook of Materials for Nanomedicine

PB - Pan Stanford Publishing Pte. Ltd.

ER -

Biomedical applications of Multi-Functional Silica-Based gold nanoshells

Abstract

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