@article{b097f3fff7ad4c83b00666216c48a5b7,
title = "Biomechanical Comparison of the Load-Sharing Capacity of High and Low Implant Density Constructs With Three Types of Pedicle Screws for the Instrumentation of Adolescent Idiopathic Scoliosis",
abstract = "Study Design: Biomechanical numerical simulation analysis of implant design and density in adolescent idiopathic scoliosis posterior instrumentation. Objectives: To evaluate the combined effect of pedicle screw design and density on deformity correction and construct load-sharing capacity. Summary of Background Data: Screw density is an area of popular study because of the impact of cost and potential patient morbidity of higher-density constructs. Using fewer screws raises concern about reduced correction and greater forces on each screw. Methods: Personalized spinal numerical models were created for five patients. The correction techniques from five spine surgeons using both a high- and a low-density implant pattern (2 vs. 1.4 ± 0.22 screws/level) with uniaxial, multiaxial, and favored angle screws were simulated. The predicted correction and forces sustained by the implants were compared. The postoperative load-sharing capacity of a high- and a low-density construct, with or without crosslinks, was compared by simulating daily activities motions. Results: The major coronal curve correction was similar with high- and low-density constructs (73% ± 10% vs. 72% ± 10%; p >.05) but was higher when using uniaxial (77% ± 8%) compared to multiaxial (69% ± 11%) and favored angle screws (71% ± 10%; p =.009). High- and low-density constructs sustained similar intraoperative peak forces (305 ± 61 N vs. 301 ± 73 N; p =.23) regardless of screw design (all p >.05). Multiaxial and favored angle screws reduced the peak axial force by 23% and 38% compared to uniaxial screws (p =.007). The high-density construct reduced the postoperative loads sustained by each implant by 31% (p =.006). Crosslinks had no effect on load sharing (p =.23). Conclusion: High- and low-density implant patterns achieved similar coronal correction with equivalent capacity to share corrective forces regardless of the screw design. Increased degrees of freedom of the screw head reduces the capacity to correct coronal deformity but generates lower bone-screw forces. The reduced number of screws increased the postoperative forces sustained by each screw, but its effect on potential complications requires further investigations. Level of Evidence: Level 4.",
keywords = "Adolescent idiopathic scoliosis, Cross-links, Finite element analysis, Implant density, Pedicle screw",
author = "Julien Clin and {Le Nav{\'e}aux}, Franck and Mark Driscoll and Mac-Thiong, {Jean Marc} and Hubert Labelle and Stefan Parent and Shah, {Suken A.} and Lonner, {Baron S.} and Newton, {Peter O.} and Hassan Serhan",
note = "Funding Information: Author disclosures: JC (grants from DePuy Synthes Inc, during the conduct of the study; grants from K2M Inc. and NSERC, outside the submitted work), FLN (grants from DePuy Synthes, during the conduct of the study; grants from NSERC, outside the submitted work), MD (grants from DePuy Synthes Inc., during the conduct of the study; grants from K2M Inc., NSERC, FQRNT, Saltise, MITACS, MESI, and MEDTEQ; other from 2D-CrystalLab, Salus Innovations Inc., Orbital Sensing Inc., and Encapcell Inc.; personal fees from ABR Americas Ltd., outside the submitted work), JMMT (grants from DePuy Synthes Inc., during the conduct of the study; other from Spinologics Inc.; grants from Medtronic, Scoliosis Research Society, Canadian Institutes of Health Research, Canadian Foundation for Innovation, Natural Sciences and Engineering Council of Canada, Fonds de Recherche Qu{\'e}bec–Sant{\'e}, Orthopedic Research and Education Foundation, and Department of the Army–United States Army Medical Research Acquisition Activity; other from Medtronic; grants from Fonds de recherche du Qu{\'e}bec–Nature et technologies; grants from Fondation de recherche et d{\textquoteright}{\'E}ducation en Orthop{\'e}die de Montr{\'e}al [FR{\'E}OM]; nonfinancial support from Medtronic, outside the submitted work), HL (grants from Canadian Institutes of Health Research, DePuy Spine Inc., and EOS imaging Inc.; other from Spinologics Inc., outside the submitted work), SP (grants from DePuy Synthes Inc., during the conduct of the study; grants and other from Spinologics; personal fees from DePuy Synthes Spine and Medtronic; grants and personal fees from EOS-Imaging; personal fees from K2M, Scoliosis Research Society, and Canadian Spine Society; grants from Setting Scoliosis Straight Foundation, Spinologics, Canadian Institutes of Health Research, Canadian Foundation for Innovation, Natural Sciences and Engineering Council of Canada, Fonds de Recherche Qu{\'e}bec–Sant{\'e}, and Orthopedic Research and Education Foundation [OREF], outside the submitted work), SAS (grants from Setting Scoliosis Straight Foundation, personal fees from DePuy Synthes Spine, outside the submitted work), BSL (grants from Setting Scoliosis Straight Foundation, personal fees from DePuy Synthes Spine, K2M, Paradigm Spine, Spine Search, and from Ethicon; nonfinancial support from Spine Deformity Journal; grants from John and Marcella Fox Fund Grant and OREF; personal fees from Zimmer Biomet, Apifix, and Unyq Align, outside the submitted work), PON (grants and other from Setting Scoliosis Straight Foundation; other from Rady Children's Specialists; grants, personal fees, and nonfinancial support from DePuy Synthes Spine; grants and other from SRS and EOS Imaging; personal fees from Thieme Publishing; grants from NuVasive; other from Electrocore; personal fees from Cubist; other from International Pediatric Orthopedic Think Tank; grants, nonfinancial support and other from Orthopediatrics; grants, personal fees, and nonfinancial support from K2M; grants and nonfinancial support from Alphatech, outside the submitted work; in addition, PON has a patent “Anchoring Systems and Methods for Correcting Spinal Deformities” [8540754] with royalties paid to DePuy Synthes Spine, a patent “Low Profile Spinal Tethering Systems” [8123749] licensed to DePuy Spine, Inc., a patent “Screw Placement Guide” [7981117] licensed to DePuy Spine, Inc., a patent “Compressor for Use in Minimally Invasive Surgery” [7189244] licensed to DePuy Spine, Inc., and a patent “Posterior Spinal Fixation” pending to K2M), HS (other from null, outside the submitted work). Publisher Copyright: {\textcopyright} 2018 Scoliosis Research Society",
year = "2019",
month = jan,
doi = "10.1016/j.jspd.2018.06.007",
language = "English",
volume = "7",
pages = "2--10",
journal = "Spine Deformity",
issn = "2212-134X",
publisher = "Elsevier BV",
number = "1",
}