Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts

Shouyuan Jiang, Steven G. Wise, Jason C. Kovacic, Jelena Rnjak-Kovacina, Megan S. Lord

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for future research and development toward clinical use.

Original languageEnglish
Pages (from-to)369-381
Number of pages13
JournalTrends in Biotechnology
Volume42
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • biomaterial
  • blood vessel
  • extracellular matrix
  • vascular graft

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