Biomarkers of lung injury in critical care medicine: Past, present, and future

Huseyin Tunceroglu, Anjan Shah, Jahan Porhomayon, Nader D. Nader

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Acute lung injury is defined as inadequate oxygenation of the blood due to primary and secondary injuries of the lungs that limit normal gas exchange across the alveolar capillary membrane. The etiology of this clinical syndrome is generally either infectious or non-infectious. Early detection of the underlying pathophysiology of the disease and timely initiation of antibiotic therapy is crucial for treatment of infectious causes of acute lung injury. Inflammatory biomarkers have recently gained popularity in critical care medicine to differentiate these two clinically similar entities. We have reviewed a variety of biomarkers related to acute lung injury and their relative value in early diagnosis and management of these patients.

Original languageEnglish
Pages (from-to)247-261
Number of pages15
JournalImmunological Investigations
Issue number3
StatePublished - 2013
Externally publishedYes


  • Acute Lung Injury
  • Cytokine
  • Inflammatory Biomarkers.
  • Respiratory Distress


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