Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

Seymour Garte; Todor Popov; Tzveta Georgieva; Claudia Bolognesi; Emanuela Taioli; Pier Alberto Bertazzi; Peter Farmer; Domenico Franco Merlo

doi:10.1016/j.cbi.2005.03.030

Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

Seymour Garte, Todor Popov, Tzveta Georgieva, Claudia Bolognesi, Emanuela Taioli, Pier Alberto Bertazzi, Peter Farmer, Domenico Franco Merlo

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.

Original language	English
Pages (from-to)	247-251
Number of pages	5
Journal	Chemico-Biological Interactions
Volume	153-154
DOIs	https://doi.org/10.1016/j.cbi.2005.03.030
State	Published - 30 May 2005
Externally published	Yes

Keywords

Benzene
Biomarkers
DNA single strand breaks
NQO1 genotype
Petrochemical workers

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10.1016/j.cbi.2005.03.030

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@article{74a2588c9ca2469882f828cb7466e187,

title = "Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene",

abstract = "Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.",

keywords = "Benzene, Biomarkers, DNA single strand breaks, NQO1 genotype, Petrochemical workers",

author = "Seymour Garte and Todor Popov and Tzveta Georgieva and Claudia Bolognesi and Emanuela Taioli and Bertazzi, {Pier Alberto} and Peter Farmer and Merlo, {Domenico Franco}",

note = "Funding Information: This work was supported by grants from the European Commission BMH4-CT98-3785 and IC20-CT98-0201, and the American Chemistry Council No. 2430.",

year = "2005",

month = may,

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doi = "10.1016/j.cbi.2005.03.030",

language = "English",

volume = "153-154",

pages = "247--251",

journal = "Chemico-Biological Interactions",

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publisher = "Elsevier Ireland Ltd",

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T1 - Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

AU - Garte, Seymour

AU - Popov, Todor

AU - Georgieva, Tzveta

AU - Bolognesi, Claudia

AU - Taioli, Emanuela

AU - Bertazzi, Pier Alberto

AU - Farmer, Peter

AU - Merlo, Domenico Franco

N1 - Funding Information: This work was supported by grants from the European Commission BMH4-CT98-3785 and IC20-CT98-0201, and the American Chemistry Council No. 2430.

PY - 2005/5/30

Y1 - 2005/5/30

N2 - Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.

AB - Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.

KW - Benzene

KW - Biomarkers

KW - DNA single strand breaks

KW - NQO1 genotype

KW - Petrochemical workers

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VL - 153-154

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EP - 251

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

ER -

Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

Abstract

Keywords

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