TY - JOUR
T1 - Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia
AU - Boij, Roland
AU - Svensson, Judit
AU - Nilsson-Ekdahl, Kristina
AU - Sandholm, Kerstin
AU - Lindahl, Tomas L.
AU - Palonek, Elzbieta
AU - Garle, Mats
AU - Berg, Göran
AU - Ernerudh, Jan
AU - Jenmalm, Maria
AU - Matthiesen, Leif
PY - 2012/9
Y1 - 2012/9
N2 - Problem: Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study: About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results: Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions: Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.
AB - Problem: Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study: About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results: Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions: Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.
KW - Angiogenesis
KW - Chemokines
KW - Coagulation
KW - Cytokines and early onset preeclampsia
KW - Inflammation
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=84865300272&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2012.01158.x
DO - 10.1111/j.1600-0897.2012.01158.x
M3 - Article
C2 - 22626009
AN - SCOPUS:84865300272
SN - 1046-7408
VL - 68
SP - 258
EP - 270
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 3
ER -