Biomarkers in pediatric heart disease

Hythem Nawaytou, Harold S. Bernstein

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


A biomarker is a characteristic that can be used as an indicator of a biological state. A biomarker can be a clinical observation, laboratory test or an imaging parameter. In this review, we discuss the use of biomarkers in differentiating cardiac from noncardiac disease; predicting the prognosis of patients with heart failure, pulmonary hypertension and dilated cardiomyopathy; diagnosing subclinical cardiac involvement in muscular dystrophy and postchemotherapy cancer patients; detecting acute rejection following heart transplantation; diagnosing Kawasaki disease; aiding the management of postoperative cardiac patients; and managing both common (tetralogy of Fallot) and complex (single-ventricle physiology) congenital heart diseases.

Original languageEnglish
Pages (from-to)943-963
Number of pages21
JournalBiomarkers in Medicine
Issue number7
StatePublished - 1 Aug 2014


  • Kawasaki disease
  • biomarker
  • cardiomyopathy
  • cardiotoxicity
  • congenital heart disease
  • heart failure
  • heart transplant
  • natriuretic peptides
  • postoperative
  • pulmonary hypertension


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