Biomarkers for the Evaluation of Pouch Inflammation: A Systematic Review

Katherine Falloon, Benjamin L. Cohen, Ronald Ottichilo, David Grove, Florian Rieder, Taha Qazi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Ileal pouch inflammation is a common problem following ileal pouch-Anal anastomosis (IPAA). Despite its prevalence, diagnosis remains multimodal and requires endoscopy. The use of biomarkers in the prediction of and/or association with pouchitis has not been well characterized. We performed a systematic review to summarize the available evidence. Method: A search of Ovid, MEDLINE, Cochrane Library, EMBASE, and Web of Science was conducted. Inclusion criteria included studies evaluating biomarkers for the evaluation and prediction of inflammation in patients with IPAA utilizing pouchoscopy as the gold standard. Exclusion criteria included studies on the role of the microbiome or genetic markers. Results: A total of 28 studies, 5 case-control studies, and 23 observational cohort studies were identified. Fecal biomarkers were assessed in 23 studies, of which fecal calprotectin was the most commonly studied with sensitivities ranging from 57% to 92% and specificities from 19% to 92%. Six studies examined serum biomarkers. None of the serum biomarkers demonstrated a high sensitivity or specificity in association with pouch inflammation. Six studies described the longitudinal assessment of biomarkers. Of these studies, only three reported a predictive role of biomarkers in diagnosing endoscopic inflammation. Conclusions: Biomarkers have emerged as a potential option to improve the management of pouchitis given the relative ease of sampling compared to pouchoscopy. Unfortunately, the evaluated biomarkers have not consistently demonstrated accuracy in predicting inflammation. Moreover, these biomarkers have not been reliably shown to be sensitive or specific in association with endoscopic pouch inflammation to merit their widespread use in clinical practice.

Original languageEnglish
Article numberotac043
JournalCrohn's and Colitis 360
Issue number4
StatePublished - 1 Oct 2022
Externally publishedYes


  • biomarker
  • ileal pouch-Anal anastomosis
  • inflammatory bowel disease
  • pouchitis
  • ulcerative colitis


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