Biomarkers for hepatocellular carcinoma based on body fluids and feces

Ming Cheng Guan, Wei Ouyang, Ming Da Wang, Lei Liang, Na Li, Ting Ting Fu, Feng Shen, Wan Yee Lau, Qiu Ran Xu, Dong Sheng Huang, Hong Zhu, Tian Yang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Novel non-/minimally-invasive and effective approaches are urgently needed to supplement and improve current strategies for diagnosis and management of hepatocellular carcinoma (HCC). Overwhelming evidence from published studies on HCC has documented that multiple molecular biomarkers detected in body fluids and feces can be utilized in early-diagnosis, predicting responses to specific therapies, evaluating prognosis before or after therapy, as well as serving as novel therapeutic targets. Detection and analysis of proteins, metabolites, circulating nucleic acids, circulating tumor cells, and extracellular vesicles in body fluids ( e.g., blood and urine) and gut microbiota (e.g., in feces) have excellent capabilities to improve different aspects of management of HCC. Numerous studies have been devoted in identifying more promising candidate biomarkers and therapeutic targets for diagnosis, treatment, and monitoring responses of HCC to conventional therapies, most of which may improve diagnosis and management of HCC in the future. This review aimed to summarize recent advances in utilizing these biomarkers in HCC and discuss their clinical significance.

Original languageEnglish
Pages (from-to)351-365
Number of pages15
JournalWorld Journal of Gastrointestinal Oncology
Volume13
Issue number5
DOIs
StatePublished - May 2021
Externally publishedYes

Keywords

  • Biomarker
  • Blood
  • Feces
  • Gut microbiota
  • Hepatocellular carcinoma
  • Urine

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