Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects

Søren M. Bentzen; Matthew Parliament; Joseph O. Deasy; Adam Dicker; Walter J. Curran; Jacqueline P. Williams; Barry S. Rosenstein

doi:10.1016/j.ijrobp.2009.08.076

Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects

Søren M. Bentzen, Matthew Parliament, Joseph O. Deasy, Adam Dicker, Walter J. Curran, Jacqueline P. Williams, Barry S. Rosenstein

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side effects. Single nucleotide polymorphisms are briefly discussed in the context of candidate gene and genomewide association studies. The importance of adjusting for radiation dose distribution in normal tissue biomarker studies is underlined. Finally, research priorities in this field are identified and discussed.

Original language	English
Pages (from-to)	S145-S150
Journal	International Journal of Radiation Oncology Biology Physics
Volume	76
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.ijrobp.2009.08.076
State	Published - 1 Mar 2010
Externally published	Yes

Keywords

Biomarkers
Dose distribution
Normal tissue effects
Predictive factors
Radiogenomics
Single nucleotide polymorphisms
Surrogate endpoints
Toxicity

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10.1016/j.ijrobp.2009.08.076

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Bentzen, S. M., Parliament, M., Deasy, J. O., Dicker, A., Curran, W. J., Williams, J. P., & Rosenstein, B. S. (2010). Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects. International Journal of Radiation Oncology Biology Physics, 76(3 SUPPL.), S145-S150. https://doi.org/10.1016/j.ijrobp.2009.08.076

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abstract = "Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side effects. Single nucleotide polymorphisms are briefly discussed in the context of candidate gene and genomewide association studies. The importance of adjusting for radiation dose distribution in normal tissue biomarker studies is underlined. Finally, research priorities in this field are identified and discussed.",

keywords = "Biomarkers, Dose distribution, Normal tissue effects, Predictive factors, Radiogenomics, Single nucleotide polymorphisms, Surrogate endpoints, Toxicity",

author = "Bentzen, {S{\o}ren M.} and Matthew Parliament and Deasy, {Joseph O.} and Adam Dicker and Curran, {Walter J.} and Williams, {Jacqueline P.} and Rosenstein, {Barry S.}",

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doi = "10.1016/j.ijrobp.2009.08.076",

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Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects. / Bentzen, Søren M.; Parliament, Matthew; Deasy, Joseph O. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 76, No. 3 SUPPL., 01.03.2010, p. S145-S150.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy

T2 - The Importance of Dose-Volume Effects

AU - Bentzen, Søren M.

AU - Parliament, Matthew

AU - Deasy, Joseph O.

AU - Dicker, Adam

AU - Curran, Walter J.

AU - Williams, Jacqueline P.

AU - Rosenstein, Barry S.

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AB - Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side effects. Single nucleotide polymorphisms are briefly discussed in the context of candidate gene and genomewide association studies. The importance of adjusting for radiation dose distribution in normal tissue biomarker studies is underlined. Finally, research priorities in this field are identified and discussed.

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KW - Dose distribution

KW - Normal tissue effects

KW - Predictive factors

KW - Radiogenomics

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JO - International Journal of Radiation Oncology Biology Physics

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IS - 3 SUPPL.

ER -

Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects

Abstract

Keywords

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