Biomarker-specific biosensors revolutionise breast cancer diagnosis

Mugip Rahaman Abdul Wahab, Thirunavukkarasu Palaniyandi, Sandhiya Viswanathan, Gomathy Baskar, Hemapreethi Surendran, S. G.D. Gangadharan, Abimanyu Sugumaran, Asha Sivaji, Senthilkumar Kaliamoorthy, Saravanan Kumarasamy

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Breast cancer is the most common cancer among women across the globe. In order to treat breast cancer successfully, it is crucial to conduct a comprehensive assessment of the condition during its initial stages. Although mammogram screening has long been a common method of breast cancer screening, high rates of type I error and type II error results as well as radiation exposure have always been of concern. The outgrowth cancer mortality rate is primarily due to delayed diagnosis, which occurs most frequently in a metastatic III or IV stage, resulting in a poor prognosis after therapy. Traditional detection techniques require identifying carcinogenic properties of cells, such as DNA or RNA alterations, conformational changes and overexpression of certain proteins, and cell shape, which are referred to as biomarkers or analytes. These procedures are complex, long-drawn-out, and expensive. Biosensors have recently acquired appeal as low-cost, simple, and super sensitive detection methods for analysis. The biosensor approach requires the existence of biomarkers in the sample. Thus, the development of novel molecular markers for diverse forms of cancer is a rising complementary affair. These biosensor devices offer two major advantages: (1) a tiny amount of blood collected from the patient is sufficient for analysis, and (2) it could help clinicians swiftly select and decide on the best therapy routine for the individual. This review will include updates on prospective cancer markers and biosensors in cancer diagnosis, as well as the associated detection limitations, with a focus on biosensor development for marker detection.

Original languageEnglish
Article number117792
JournalClinica Chimica Acta
Volume555
DOIs
StatePublished - 1 Mar 2024
Externally publishedYes

Keywords

  • Biomarkers
  • Biosensors
  • Breast cancer
  • Diagnosis
  • Early detection

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