Biology using engineering tools: The negative feedback amplifier

Marc R. Birtwistle; Walter Kolch

doi:10.4161/cc.10.13.16245

Biology using engineering tools: The negative feedback amplifier

Marc R. Birtwistle, Walter Kolch

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues¹ presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.

Original language	English
Pages (from-to)	2069-2076
Number of pages	8
Journal	Cell Cycle
Volume	10
Issue number	13
DOIs	https://doi.org/10.4161/cc.10.13.16245
State	Published - 1 Jul 2011
Externally published	Yes

Keywords

Mitogen activated protein kinase
Negative feedback
Quantitative modeling
Signal transduction
Spatiotemporal dynamics

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title = "Biology using engineering tools: The negative feedback amplifier",

abstract = "Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues1 presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.",

keywords = "Mitogen activated protein kinase, Negative feedback, Quantitative modeling, Signal transduction, Spatiotemporal dynamics",

author = "Birtwistle, \{Marc R.\} and Walter Kolch",

note = "Funding Information: Outlook for Medicine: M.R.B. and W.K. acknowledge Science Fighting against Foundation Ireland under Grant No. 06/ the Negative Feedback Amplifier CE/B1129, and M.R.B. acknowledges a Marie Curie International Incoming Given the multitude of strong negative Fellowship (236758) and an EMBO long-feedbacks operating in many different term fellowship (ALTF 815-2010).",

year = "2011",

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doi = "10.4161/cc.10.13.16245",

language = "English",

volume = "10",

pages = "2069--2076",

journal = "Cell Cycle",

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T1 - Biology using engineering tools

T2 - The negative feedback amplifier

AU - Birtwistle, Marc R.

AU - Kolch, Walter

N1 - Funding Information: Outlook for Medicine: M.R.B. and W.K. acknowledge Science Fighting against Foundation Ireland under Grant No. 06/ the Negative Feedback Amplifier CE/B1129, and M.R.B. acknowledges a Marie Curie International Incoming Given the multitude of strong negative Fellowship (236758) and an EMBO long-feedbacks operating in many different term fellowship (ALTF 815-2010).

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues1 presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.

AB - Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues1 presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.

KW - Mitogen activated protein kinase

KW - Negative feedback

KW - Quantitative modeling

KW - Signal transduction

KW - Spatiotemporal dynamics

UR - https://www.scopus.com/pages/publications/79959970760

U2 - 10.4161/cc.10.13.16245

DO - 10.4161/cc.10.13.16245

M3 - Review article

C2 - 21572255

AN - SCOPUS:79959970760

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VL - 10

SP - 2069

EP - 2076

JO - Cell Cycle

JF - Cell Cycle

IS - 13

ER -

Biology using engineering tools: The negative feedback amplifier

Abstract

Keywords

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