Biology of TGF-β in knockout and transgenic mouse models

E. P. Bottinger; J. J. Letterio; A. B. Roberts

doi:10.1038/ki.1997.185

Biology of TGF-β in knockout and transgenic mouse models

E. P. Bottinger
, J. J. Letterio
, A. B. Roberts

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Abstract

This paper reviews the basic biology and biochemistry of the TGF-β isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-β expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-β1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.

Original language	English
Pages (from-to)	1355-1360
Number of pages	6
Journal	Kidney International
Volume	51
Issue number	5
DOIs	https://doi.org/10.1038/ki.1997.185
State	Published - 1997
Externally published	Yes

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abstract = "This paper reviews the basic biology and biochemistry of the TGF-β isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-β expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-β1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.",

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Biology of TGF-β in knockout and transgenic mouse models

Abstract

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