Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection

Viswanathan Lakshmanan; Galit Alter; Marcus Altfeld; Nina Bhardwaj

doi:10.1097/COH.0b013e32810996db

Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection

Viswanathan Lakshmanan, Galit Alter, Marcus Altfeld, Nina Bhardwaj

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

PURPOSE: This review summarizes recent literature on the biology of dendritic cells and natural killer cells in HIV-1 infection and the importance of crosstalk between them in the development of strong antiviral immunity. RECENT FINDINGS: Type I interferons produced by dendritic cells in response to HIV-1 have been suggested to act as a double-edged sword, stemming HIV-1 replication on the one hand and causing T-cell loss on the other. Recent epidemiologic evidence demonstrates a strong association between the natural killer cell receptor KIR3DS1 (along with its presumed ligand HLA-B Bw4-80I) in the control of HIV-1 replication. SUMMARY: Dendritic and natural killer cells play a central role in the innate immune response to viral infections through both the direct elimination of infected cells and modulation of each other's function.

Original language	English
Pages (from-to)	189-200
Number of pages	12
Journal	Current Opinion in HIV and AIDS
Volume	2
Issue number	3
DOIs	https://doi.org/10.1097/COH.0b013e32810996db
State	Published - May 2007
Externally published	Yes

Keywords

HIV-1
Interferon
Natural killer cell
Plasmacytoid dendritic cell

Access to Document

10.1097/COH.0b013e32810996db

Cite this

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abstract = "PURPOSE: This review summarizes recent literature on the biology of dendritic cells and natural killer cells in HIV-1 infection and the importance of crosstalk between them in the development of strong antiviral immunity. RECENT FINDINGS: Type I interferons produced by dendritic cells in response to HIV-1 have been suggested to act as a double-edged sword, stemming HIV-1 replication on the one hand and causing T-cell loss on the other. Recent epidemiologic evidence demonstrates a strong association between the natural killer cell receptor KIR3DS1 (along with its presumed ligand HLA-B Bw4-80I) in the control of HIV-1 replication. SUMMARY: Dendritic and natural killer cells play a central role in the innate immune response to viral infections through both the direct elimination of infected cells and modulation of each other's function.",

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AU - Lakshmanan, Viswanathan

AU - Alter, Galit

AU - Altfeld, Marcus

AU - Bhardwaj, Nina

PY - 2007/5

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N2 - PURPOSE: This review summarizes recent literature on the biology of dendritic cells and natural killer cells in HIV-1 infection and the importance of crosstalk between them in the development of strong antiviral immunity. RECENT FINDINGS: Type I interferons produced by dendritic cells in response to HIV-1 have been suggested to act as a double-edged sword, stemming HIV-1 replication on the one hand and causing T-cell loss on the other. Recent epidemiologic evidence demonstrates a strong association between the natural killer cell receptor KIR3DS1 (along with its presumed ligand HLA-B Bw4-80I) in the control of HIV-1 replication. SUMMARY: Dendritic and natural killer cells play a central role in the innate immune response to viral infections through both the direct elimination of infected cells and modulation of each other's function.

AB - PURPOSE: This review summarizes recent literature on the biology of dendritic cells and natural killer cells in HIV-1 infection and the importance of crosstalk between them in the development of strong antiviral immunity. RECENT FINDINGS: Type I interferons produced by dendritic cells in response to HIV-1 have been suggested to act as a double-edged sword, stemming HIV-1 replication on the one hand and causing T-cell loss on the other. Recent epidemiologic evidence demonstrates a strong association between the natural killer cell receptor KIR3DS1 (along with its presumed ligand HLA-B Bw4-80I) in the control of HIV-1 replication. SUMMARY: Dendritic and natural killer cells play a central role in the innate immune response to viral infections through both the direct elimination of infected cells and modulation of each other's function.

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KW - Interferon

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Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection

Abstract

Keywords

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