Biological Ion Exchanger Resins: II. QUERP Water and Ion Exchange Selectivity

Raymond Damadian; Michael Goldsmith; K. S. Zaner

doi:10.1016/S0006-3495(71)86252-5

Biological Ion Exchanger Resins: II. QUERP Water and Ion Exchange Selectivity

Raymond Damadian, Michael Goldsmith, K. S. Zaner

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Biological selectivity is shown to vary with medium osmotic strength and temperature. Selectivity reversals occur at 4°C and at an external osmolality of 0.800 indicating that intracellular hydration and endosolvent (intracellular water) structure are important determinants in selectivity. Magnetic resonance measurements of line width by steady-state nuclear magnetic resonance (NMR) indicate a difference in the intracellular water signal of 16 Hz between the K form and Na form of Escherichia coli, providing additional evidence that changes in the ionic composition of cells are accompanied by changes in endosolvent structure. The changes were found to be consistent with the thermodynamic and magnetic resonance properties of aqueous electrolyte solutions. Calculation of the dependence of ion-pairing forces on medium dielectric reinforces the role of endosolvent structure in determining ion exchange selectivity.

Original language	English
Pages (from-to)	761-772
Number of pages	12
Journal	Biophysical Journal
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/S0006-3495(71)86252-5
State	Published - 1971

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@article{65760978ed7a49d3b373cc10093d0f32,

title = "Biological Ion Exchanger Resins: II. QUERP Water and Ion Exchange Selectivity",

abstract = "Biological selectivity is shown to vary with medium osmotic strength and temperature. Selectivity reversals occur at 4°C and at an external osmolality of 0.800 indicating that intracellular hydration and endosolvent (intracellular water) structure are important determinants in selectivity. Magnetic resonance measurements of line width by steady-state nuclear magnetic resonance (NMR) indicate a difference in the intracellular water signal of 16 Hz between the K form and Na form of Escherichia coli, providing additional evidence that changes in the ionic composition of cells are accompanied by changes in endosolvent structure. The changes were found to be consistent with the thermodynamic and magnetic resonance properties of aqueous electrolyte solutions. Calculation of the dependence of ion-pairing forces on medium dielectric reinforces the role of endosolvent structure in determining ion exchange selectivity.",

author = "Raymond Damadian and Michael Goldsmith and Zaner, {K. S.}",

note = "Funding Information: The author wishes to acknowledge the secretarial assistance of Mrs. Anne Russo in the preparation of this manuscript. Dr. Damadian is a Career Investigator of the Health Research Council of the City of New York. The research in this paper has been supported by grants from the Health Research Council of the City of New York (U-1891), the New York Heart Association (12-1740A), and the National Institutes of Health (1 ROI AM14890-01).",

year = "1971",

doi = "10.1016/S0006-3495(71)86252-5",

language = "English",

volume = "11",

pages = "761--772",

journal = "Biophysical Journal",

issn = "0006-3495",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Biological Ion Exchanger Resins

T2 - II. QUERP Water and Ion Exchange Selectivity

AU - Damadian, Raymond

AU - Goldsmith, Michael

AU - Zaner, K. S.

N1 - Funding Information: The author wishes to acknowledge the secretarial assistance of Mrs. Anne Russo in the preparation of this manuscript. Dr. Damadian is a Career Investigator of the Health Research Council of the City of New York. The research in this paper has been supported by grants from the Health Research Council of the City of New York (U-1891), the New York Heart Association (12-1740A), and the National Institutes of Health (1 ROI AM14890-01).

PY - 1971

Y1 - 1971

N2 - Biological selectivity is shown to vary with medium osmotic strength and temperature. Selectivity reversals occur at 4°C and at an external osmolality of 0.800 indicating that intracellular hydration and endosolvent (intracellular water) structure are important determinants in selectivity. Magnetic resonance measurements of line width by steady-state nuclear magnetic resonance (NMR) indicate a difference in the intracellular water signal of 16 Hz between the K form and Na form of Escherichia coli, providing additional evidence that changes in the ionic composition of cells are accompanied by changes in endosolvent structure. The changes were found to be consistent with the thermodynamic and magnetic resonance properties of aqueous electrolyte solutions. Calculation of the dependence of ion-pairing forces on medium dielectric reinforces the role of endosolvent structure in determining ion exchange selectivity.

AB - Biological selectivity is shown to vary with medium osmotic strength and temperature. Selectivity reversals occur at 4°C and at an external osmolality of 0.800 indicating that intracellular hydration and endosolvent (intracellular water) structure are important determinants in selectivity. Magnetic resonance measurements of line width by steady-state nuclear magnetic resonance (NMR) indicate a difference in the intracellular water signal of 16 Hz between the K form and Na form of Escherichia coli, providing additional evidence that changes in the ionic composition of cells are accompanied by changes in endosolvent structure. The changes were found to be consistent with the thermodynamic and magnetic resonance properties of aqueous electrolyte solutions. Calculation of the dependence of ion-pairing forces on medium dielectric reinforces the role of endosolvent structure in determining ion exchange selectivity.

UR - http://www.scopus.com/inward/record.url?scp=0015117565&partnerID=8YFLogxK

U2 - 10.1016/S0006-3495(71)86252-5

DO - 10.1016/S0006-3495(71)86252-5

M3 - Article

C2 - 4943653

AN - SCOPUS:0015117565

SN - 0006-3495

VL - 11

SP - 761

EP - 772

JO - Biophysical Journal

JF - Biophysical Journal

IS - 9

ER -

Biological Ion Exchanger Resins: II. QUERP Water and Ion Exchange Selectivity

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