Biologic models of traumatic memories and post-traumatic stress disorder: The role of neural networks

Alexander C. McFarlane, Rachel Yehuda, C. Richard Clark

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Neural networks and their behavior provide an information-processing model for initiation and maintenance of the biologic aspects of post-traumatic stress disorder (PTSD). The repeated replaying of the intrusive and distressing recollections that follow a trauma modifies the structure of the neural networks involved in the processing of traumatic memories. The hypothesis is proposed that this repetition instigates the mechanisms of iterative learning, top-down activation, and pruning. The development of the symptoms of PTSD can be explained by current knowledge about modeling disturbances of parallel distributing processing. The noradrenergic neurons play a central role in coordinating the interaction of multiple cortical regions, which is an essential aspect of parallel distributed processing. Disturbances of this system in PTSD are likely to be manifest as a dysfunctional modulation of working memory and involuntary traumatic recollection. Modifications of neural networks have a secondary effect of kindling in the hippocampus that further moderates the individual's sensitivity to a range of stressors. Therefore, a neural network model of PTSD provides a method for conceptualizing the onset of PTSD symptoms and their subsequent modification with the passage of time.

Original languageEnglish
Pages (from-to)253-270
Number of pages18
JournalPsychiatric Clinics of North America
Issue number2
StatePublished - 1 Jan 2002
Externally publishedYes


Dive into the research topics of 'Biologic models of traumatic memories and post-traumatic stress disorder: The role of neural networks'. Together they form a unique fingerprint.

Cite this