Biologic Heterogeneity and Psychiatric Research: Platelet MAO Activity as a Case Study

Monte S. Buchsbaum, Ronald O. Rieder

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

This article examines current research strategies in biological psychiatry and the possible effects of biological heterogeneity on these strategies. First, the limited power of t test comparisons of measurements obtained from groups of patients and controls is demonstrated through a computer simulation. Second, we examine statistically the data from 14 recent platelet MAO studies to see if the heterogeneity in results of these studies could relate to an underlying biological heterogeneity. Finally, we suggest research methods we believe may be more useful than the current standard paradigm for elucidating the biological etiologies of psychiatric syndromes.

Original languageEnglish
Pages (from-to)1163-1169
Number of pages7
JournalArchives of General Psychiatry
Volume36
Issue number11
DOIs
StatePublished - Oct 1979
Externally publishedYes

Fingerprint

Dive into the research topics of 'Biologic Heterogeneity and Psychiatric Research: Platelet MAO Activity as a Case Study'. Together they form a unique fingerprint.

Cite this