Biologic comparison of partial breast irradiation protocols

Barry S. Rosenstein, Stella C. Lymberis, Silvia C. Formenti

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

To analyze the dose/fractionation schedules currently used in ongoing clinical trials of partial breast irradiation (PBI) by comparing their biologically effective dose (BED) values to those of three standard whole breast protocols commonly used after segmental mastectomy in the treatment of breast cancer. The BED equation derived from the linear-quadratic model for radiation-induced cell killing was used to calculate the BEDs for three commonly used whole breast radiotherapy regimens, in addition to a variety of external beam radiotherapy, as well as high-dose-rate and low-dose-rate brachytherapy, PBI protocols. The BED values of most PBI protocols resulted in tumor control BEDs roughly equivalent to a 50-Gy standard treatment, but consistently lower than the BEDs for regimens in which the tumor bed receives a total dose of either 60 Gy or 66 Gy. The BED values calculated for the acute radiation responses of erythema and desquamation were nearly all lower for the PBI schedules, and the late-response BEDs for most PBI regimens were in a similar range to the BEDs for the standard treatments. Biologically effective dose modeling raises the concern that inadequate doses might be delivered by PBI to ensure optimal in-field tumor control.

Original languageEnglish
Pages (from-to)1393-1404
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume60
Issue number5
DOIs
StatePublished - 1 Dec 2004

Keywords

  • Biologically effective dose
  • Breast cancer
  • Partial breast irradiation

Fingerprint

Dive into the research topics of 'Biologic comparison of partial breast irradiation protocols'. Together they form a unique fingerprint.

Cite this