Bioengineering Organoids for Disease Modeling and Drug Discovery

Organoid technology has been used to model diseases across different organ systems, drug screening, and regenerative medicine. Organoid technology better mimics human physiology and can provide a better alternative to in vivo animal models. Recent advances in organoid technology, including developing the novel organoid platform, engineering complex organoids, and introducing pathological aspects, have provided significant progress toward producing miniaturized tissue or organs on a dish. Novel technologies like high-resolution 3D imaging, organ on a chip, 3D printing, gene manipulation, nanotechnology advances, and single-cell sequencing have led to a massive thrust in the organoid technology that can provide a unique insight into the behavior of stem cells, cater to preclinical research and theranostics (therapy plus diagnostics).