Biodegradable poly(esters) for the controlled delivery of vaccines

R. J. Linhardt, H. T. Wang, D. R. Flanagan, E. Schmitt, H. Palmer

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations

Abstract

Biodegradable polymers have a variety of potential biomedical applications in addition to their current use as suture material. Biodegradable polymers used in controlled release applications are primarily insoluble and undergo chemical hydrolysis to soluble monomeric or oligomeric units. This research focuses on microspheres prepared from three biodegradable poly(esters) as potential carriers of recombinant proteins for vaccine use. Experiments show matrix life-times compatible with vaccine applications. Release studies demonstrate a delay of up to three weeks is possible making these formulations potentially useful for vaccine applications.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume63
StatePublished - 1990
Externally publishedYes
EventProceedings of the ACS Division of Polymeric Materials: Science and Engineering - Washington, DC, USA
Duration: 26 Aug 199031 Aug 1990

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