Bioartificial organ support for hepatic, renal, and hematologic failure

Patrick J. Maguire, Christopher Stevens, H. David Humes, Aryeh Shander, Neil A. Halpern, Stephen M. Pastores

Research output: Contribution to journalArticlepeer-review


The current strategy to the treatment of SIRS and MODS uses a multidisciplinary approach that emphasizes supportive therapy. Herein, we have presented a futuristic approach that focuses on replacing the function of failed organs using bioartificial technology (Table 1). Bioartificial organ technology may allow the intensivist to provide physiologic organ replacement either as a bridge to transplantation or as a 'time-buying' element until native organs that have become acutely dysfunctional or nonfunctional in a variety of clinical settings, can recover their function or regenerate their mass. As bioartificial organ technology matures, it is conceivable as an ultimate goal that non-immunogenic bioartificial organs would be miniaturized or redesigned and acutely placed within the intracorporeal space as replacement organs.

Original languageEnglish
Pages (from-to)681-694
Number of pages14
JournalCritical Care Clinics
Issue number4
StatePublished - 2000


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