Bilateral periorbital leukemia cutis presenting as suspected cellulitis

Lalita Gupta; Melissa A. Levoska; Timmie Sharma; Kord Honda; Mark A. Prendes

doi:10.1080/01676830.2021.1893343

Bilateral periorbital leukemia cutis presenting as suspected cellulitis

Lalita Gupta, Melissa A. Levoska, Timmie Sharma, Kord Honda, Mark A. Prendes

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.

Original language	English
Pages (from-to)	506-508
Number of pages	3
Journal	Orbit
Volume	41
Issue number	4
DOIs	https://doi.org/10.1080/01676830.2021.1893343
State	Published - 2022
Externally published	Yes

Keywords

Acute myeloid leukemia
IDH2 mutation
enasidenib
leukemia cutis
periorbital edema

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10.1080/01676830.2021.1893343

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title = "Bilateral periorbital leukemia cutis presenting as suspected cellulitis",

abstract = "Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.",

keywords = "Acute myeloid leukemia, IDH2 mutation, enasidenib, leukemia cutis, periorbital edema",

author = "Lalita Gupta and Levoska, {Melissa A.} and Timmie Sharma and Kord Honda and Prendes, {Mark A.}",

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year = "2022",

doi = "10.1080/01676830.2021.1893343",

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volume = "41",

pages = "506--508",

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T1 - Bilateral periorbital leukemia cutis presenting as suspected cellulitis

AU - Gupta, Lalita

AU - Levoska, Melissa A.

AU - Sharma, Timmie

AU - Honda, Kord

AU - Prendes, Mark A.

PY - 2022

Y1 - 2022

N2 - Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.

AB - Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.

KW - Acute myeloid leukemia

KW - IDH2 mutation

KW - enasidenib

KW - leukemia cutis

KW - periorbital edema

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DO - 10.1080/01676830.2021.1893343

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AN - SCOPUS:85102169918

SN - 0167-6830

VL - 41

SP - 506

EP - 508

JO - Orbit

JF - Orbit

IS - 4

ER -

Bilateral periorbital leukemia cutis presenting as suspected cellulitis

Abstract

Keywords

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