Beyond supersecondary structure: The global properties of protein sequences

S. Rackovsky

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Analysis of the global properties of protein sequences, rather than single-site or local properties, has been shown to lead to new understanding of folding and function. Here we describe the use of software which can describe sequences numerically in an orthonormal fashion, Fourier-analyze those sequences, and verify the statistical signi fi cance of the resulting Fourier coef fi cients. The resulting parameters can be used to study problems involving sequences from a unique perspective.

Original languageEnglish
Title of host publicationProtein Supersecondary Structures
PublisherHumana Press Inc.
Number of pages8
ISBN (Print)9781627030649
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Fourier analysis
  • Global representation
  • Sequence analysis


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