Beyond "cirrhosis"

Prodromos Hytiroglou, Dale C. Snover, Venancio Alves, Charles Balabaud, Prithi S. Bhathal, Paulette Bioulac-Sage, James M. Crawford, Amar P. Dhillon, Linda Ferrell, Maria Guido, Yasuni Nakanuma, Valerie Paradis, Alberto Quaglia, Neil D. Theise, Swan N. Thung, Wilson M.S. Tsui, Dirk J. Van Leeuwen

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

"Cirrhosis" is a morphologic term that has been used for almost 200 years to denote the end stage of a variety of chronic liver diseases. The term implies a condition with adverse prognosis due to the well-known complications of portal hypertension, hepatocellular carcinoma, and liver failure. However, recent advances in the diagnosis and treatment of chronic liver diseases have changed the natural history of cirrhosis significantly. This consensus document by the International Liver Pathology Study Group challenges the usefulness of the word cirrhosis in modern medicine and suggests that this is an appropriate time to consider discontinuing the use of this term. The role of pathologists should evolve to the diagnosis of advanced stage of chronic liver disease, with emphasis on etiology, grade of activity, features suggestive of progression or regression, presence of other diseases, and risk factors for malignancy, within the perspective of an integrated clinicopathologic assessment.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume137
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Cirrhosis
  • Classification
  • Disease
  • Liver
  • Nomenclature
  • Regression
  • Stage

Fingerprint

Dive into the research topics of 'Beyond "cirrhosis"'. Together they form a unique fingerprint.

Cite this