Better together: Non-additive interactions between schizophrenia risk genes

P. J.Michael Deans; Kristen J. Brennand

doi:10.1016/j.xgen.2023.100403

Better together: Non-additive interactions between schizophrenia risk genes

P. J.Michael Deans, Kristen J. Brennand

Research output: Contribution to journal › Comment/debate

Abstract

Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.

Original language	English
Article number	100403
Journal	Cell Genomics
Volume	3
Issue number	9
DOIs	https://doi.org/10.1016/j.xgen.2023.100403
State	Published - 13 Sep 2023
Externally published	Yes

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title = "Better together: Non-additive interactions between schizophrenia risk genes",

abstract = "Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.",

author = "Deans, {P. J.Michael} and Brennand, {Kristen J.}",

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AU - Brennand, Kristen J.

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AB - Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.

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DO - 10.1016/j.xgen.2023.100403

M3 - Comment/debate

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SN - 2666-979X

VL - 3

JO - Cell Genomics

JF - Cell Genomics

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Better together: Non-additive interactions between schizophrenia risk genes

Abstract

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