Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429

Robert J. DeVita; William R. Schoen; Michael H. Fisher; Alison J. Frontier; Judith M. Pisano; Matthew J. Wyvratt; Kang Cheng; Wanda W.S. Chan; Bridget S. Butler; Gerard J. Hickey; Thomas M. Jacks; Roy G. Smith

doi:10.1016/S0960-894X(00)80080-3

Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429

Robert J. DeVita
, William R. Schoen
, Michael H. Fisher
, Alison J. Frontier
, Judith M. Pisano
, Matthew J. Wyvratt
, Kang Cheng
, Wanda W.S. Chan
, Bridget S. Butler
, Gerard J. Hickey
, Thomas M. Jacks
, Roy G. Smith

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A variety of 2′-carboxamides was investigated as replacements for the 2′-tetrazole moiety of L-692,429. Investigation of the structure-activity relationships of the carboxamide series determined that primary and secondary carboxamides are potent growth hormone secretagogues in vitro. L-700,653 (11) was identified as an orally active GH secretagogue in dogs.

Original language	English
Pages (from-to)	2249-2254
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(00)80080-3
State	Published - 22 Sep 1994
Externally published	Yes

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DeVita, R. J., Schoen, W. R., Fisher, M. H., Frontier, A. J., Pisano, J. M., Wyvratt, M. J., Cheng, K., Chan, W. W. S., Butler, B. S., Hickey, G. J., Jacks, T. M., & Smith, R. G. (1994). Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429. Bioorganic and Medicinal Chemistry Letters, 4(18), 2249-2254. https://doi.org/10.1016/S0960-894X(00)80080-3

@article{d39a612ca0274c38891cb404a3118fe1,

title = "Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429",

abstract = "A variety of 2′-carboxamides was investigated as replacements for the 2′-tetrazole moiety of L-692,429. Investigation of the structure-activity relationships of the carboxamide series determined that primary and secondary carboxamides are potent growth hormone secretagogues in vitro. L-700,653 (11) was identified as an orally active GH secretagogue in dogs.",

author = "DeVita, \{Robert J.\} and Schoen, \{William R.\} and Fisher, \{Michael H.\} and Frontier, \{Alison J.\} and Pisano, \{Judith M.\} and Wyvratt, \{Matthew J.\} and Kang Cheng and Chan, \{Wanda W.S.\} and Butler, \{Bridget S.\} and Hickey, \{Gerard J.\} and Jacks, \{Thomas M.\} and Smith, \{Roy G.\}",

year = "1994",

month = sep,

day = "22",

doi = "10.1016/S0960-894X(00)80080-3",

language = "English",

volume = "4",

pages = "2249--2254",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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DeVita, RJ, Schoen, WR, Fisher, MH, Frontier, AJ, Pisano, JM, Wyvratt, MJ, Cheng, K, Chan, WWS, Butler, BS, Hickey, GJ, Jacks, TM & Smith, RG 1994, 'Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429', Bioorganic and Medicinal Chemistry Letters, vol. 4, no. 18, pp. 2249-2254. https://doi.org/10.1016/S0960-894X(00)80080-3

TY - JOUR

T1 - Benzolactam growth hormone secretagogues

T2 - Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429

AU - DeVita, Robert J.

AU - Schoen, William R.

AU - Fisher, Michael H.

AU - Frontier, Alison J.

AU - Pisano, Judith M.

AU - Wyvratt, Matthew J.

AU - Cheng, Kang

AU - Chan, Wanda W.S.

AU - Butler, Bridget S.

AU - Hickey, Gerard J.

AU - Jacks, Thomas M.

AU - Smith, Roy G.

PY - 1994/9/22

Y1 - 1994/9/22

N2 - A variety of 2′-carboxamides was investigated as replacements for the 2′-tetrazole moiety of L-692,429. Investigation of the structure-activity relationships of the carboxamide series determined that primary and secondary carboxamides are potent growth hormone secretagogues in vitro. L-700,653 (11) was identified as an orally active GH secretagogue in dogs.

AB - A variety of 2′-carboxamides was investigated as replacements for the 2′-tetrazole moiety of L-692,429. Investigation of the structure-activity relationships of the carboxamide series determined that primary and secondary carboxamides are potent growth hormone secretagogues in vitro. L-700,653 (11) was identified as an orally active GH secretagogue in dogs.

UR - https://www.scopus.com/pages/publications/0028109350

U2 - 10.1016/S0960-894X(00)80080-3

DO - 10.1016/S0960-894X(00)80080-3

M3 - Article

AN - SCOPUS:0028109350

SN - 0960-894X

VL - 4

SP - 2249

EP - 2254

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Benzolactam growth hormone secretagogues: Carboxamides as replacements for the 2′-tetrazole moiety of L-692,429

Abstract

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