Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.

A. L. Lozovatskiǐ; V. A. Ostashevskiǐ; O. M. Perminova; V. A. Kozlov; I. B. Tsyrlov

Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.

Translated title of the contribution: Benz(a)anthracene and 2,3,7,8-tetrachloro dibenzo(p)dioxin modulate mitogen-stimulated proliferation of lymphocytes

A. L. Lozovatskiǐ, V. A. Ostashevskiǐ, O. M. Perminova, V. A. Kozlov, I. B. Tsyrlov

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.

Translated title of the contribution	Benz(a)anthracene and 2,3,7,8-tetrachloro dibenzo(p)dioxin modulate mitogen-stimulated proliferation of lymphocytes
Original language	Russian
Pages (from-to)	569-571
Number of pages	3
Journal	Byulleten Eksperimentalnoi Biologii i Meditsiny
Volume	109
Issue number	6
State	Published - Jun 1990

Cite this

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title = "Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.",

abstract = "The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.",

author = "Lozovatskiǐ, {A. L.} and Ostashevskiǐ, {V. A.} and Perminova, {O. M.} and Kozlov, {V. A.} and Tsyrlov, {I. B.}",

year = "1990",

month = jun,

language = "Russian",

volume = "109",

pages = "569--571",

journal = "Byulleten Eksperimentalnoi Biologii i Meditsiny",

issn = "0365-9615",

publisher = "Rossiiskaya Akademiya Meditsinskikh Nauk",

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T1 - Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.

AU - Lozovatskiǐ, A. L.

AU - Ostashevskiǐ, V. A.

AU - Perminova, O. M.

AU - Kozlov, V. A.

AU - Tsyrlov, I. B.

PY - 1990/6

Y1 - 1990/6

N2 - The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.

AB - The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.

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M3 - Article

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AN - SCOPUS:0025439170

SN - 0365-9615

VL - 109

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EP - 571

JO - Byulleten Eksperimentalnoi Biologii i Meditsiny

JF - Byulleten Eksperimentalnoi Biologii i Meditsiny

IS - 6

ER -

Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.

Abstract

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