Bent into shape: Folded peptides to mimic protein structure and modulate protein function

Haley I. Merritt; Nicholas Sawyer; Paramjit S. Arora

doi:10.1002/pep2.24145

Bent into shape: Folded peptides to mimic protein structure and modulate protein function

Haley I. Merritt, Nicholas Sawyer, Paramjit S. Arora

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here, we review contemporary methods to reproduce loop, helix, sheet, and coiled-coil conformations in short peptides.

Original language	English
Article number	e24145
Journal	Peptide Science
Volume	112
Issue number	1
DOIs	https://doi.org/10.1002/pep2.24145
State	Published - 1 Jan 2020
Externally published	Yes

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title = "Bent into shape: Folded peptides to mimic protein structure and modulate protein function",

abstract = "Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here, we review contemporary methods to reproduce loop, helix, sheet, and coiled-coil conformations in short peptides.",

author = "Merritt, {Haley I.} and Nicholas Sawyer and Arora, {Paramjit S.}",

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T2 - Folded peptides to mimic protein structure and modulate protein function

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AU - Sawyer, Nicholas

AU - Arora, Paramjit S.

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Y1 - 2020/1/1

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AB - Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here, we review contemporary methods to reproduce loop, helix, sheet, and coiled-coil conformations in short peptides.

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DO - 10.1002/pep2.24145

M3 - Review article

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VL - 112

JO - Peptide Science

JF - Peptide Science

IS - 1

M1 - e24145

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Bent into shape: Folded peptides to mimic protein structure and modulate protein function

Abstract

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