Benign Transient Hyperphosphatasia and HIV Infection

Ilene Fennoy, Danielle Laraque

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The disorder, benign transient hyperphosphatasia, has been defined previously as a condition occurring in a normal child with spontaneous, transient elevation of alkaline phosphatase. We report three cases of hyperphosphatasia in patients with congenital HIV infection and underlying liver disease which appear to satisfy the criteria for benign transient hyperphosphatasia despite the presence of chronic disease. These three children, when compared with three normal children with transient hyperphosphatasia exhibited similar patterns of change in serum alkaline phosphatase. Extreme elevation of serum alkaline phosphatase in HIV infected patients does not of itself suggest alterations in clinical status nor indicate the need for extensive evaluation.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalClinical Pediatrics
Issue number4
StatePublished - Apr 1989
Externally publishedYes


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