Belatacept Conversion in an HIV-Positive Kidney Transplant Recipient With Prolonged Delayed Graft Function

Z. Ebcioglu, C. Liu, R. Shapiro, M. Rana, F. Salem, S. Florman, S. Huprikar, V. Nair

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We report an HIV-positive renal transplant recipient with delayed graft function who was converted from tacrolimus to belatacept in an attempt to improve renal function. The patient had kidney biopsies at 4 and 8 weeks posttransplant that revealed acute tubular necrosis and mild fibrosis. After 14 weeks of delayed function, belatacept was initiated and tacrolimus was weaned off. Shortly after discontinuing tacrolimus, renal function began to improve. The patient was able to discontinue dialysis 21 weeks posttransplant. HIV viral load was undetectable at last follow-up. To our knowledge, this is the first report of belatacept use in a patient with HIV.

Original languageEnglish
Pages (from-to)3278-3281
Number of pages4
JournalAmerican Journal of Transplantation
Volume16
Issue number11
DOIs
StatePublished - 1 Nov 2016

Keywords

  • clinical research/practice
  • delayed graft function (DGF)
  • fusion proteins and monoclonal antibodies: belatacept
  • immunosuppressant
  • immunosuppression/immune modulation
  • immunosuppressive regimens
  • infection and infectious agents
  • infectious disease
  • kidney transplantation/nephrology
  • maintenance
  • viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)

Fingerprint

Dive into the research topics of 'Belatacept Conversion in an HIV-Positive Kidney Transplant Recipient With Prolonged Delayed Graft Function'. Together they form a unique fingerprint.

Cite this