Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Weinan Zhao, Qing Li, Yu Ma, Zhiyong Wang, Bingqian Fan, Xiaojing Zhai, Mengfan Hu, Qing Wang, Moruo Zhang, Chunyan Zhang, Yixue Qin, Sha Sha, Zhonghao Gan, Fan Ye, Yihan Xia, Guangchao Zhang, Li Yang, Shiya Zou, Zheng Xu, Sunhui XiaYumei Yu, Mannan Abdul, Jun Xia Yang, Jun Li Cao, Fang Zhou, Hongxing Zhang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test. These findings implicate those psychiatry- and pain-related behaviors in normal female C57BL/6J mice appear to be relatively consistent throughout the estrous cycle; the estrous cycle might not be a main contributor to female C57BL/6J mice’s variability of behaviors.

Original languageEnglish
Article number650793
JournalFrontiers in Neuroscience
Volume15
DOIs
StatePublished - 6 Apr 2021
Externally publishedYes

Keywords

  • behavior
  • estrous cycle
  • female mice
  • pain
  • psychiatry

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