Behavioral profile of CCK2 receptor-deficient mice

Valérie Daugé, Angélique Sebret, Françoise Beslot, Toshimitsu Matsui, Bernard P. Roques

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

CCK2 receptor-deficient mice were used to investigate in vivo the role of this receptor in behavior. Mutant mice showed a neuromuscular impairment in the traction and rotarod tests but not in the chimney test. Brain cholecystokinin has been shown to participate in stress-related behaviors. However, CCK2 receptor-deficient mice did not show behavioral modifications compared to wild-type mice in the elevated plus maze and in the motility conditioned suppression test, indicating that compensatory mechanisms very likely occur following CCK2 receptor invalidation. On the other hand, a hyperlocomotor activity was observed in actimeter which can be related to an impairment in environmental habituation. Finally, CCK2 receptor-deficient mice showed an impairment of performance in the spontaneous alternation behavior as expected from the opposite effects evoked by CCK2 agonists, supporting the physiological role of CCK2 receptors in attention and/or memory processes. This result is reinforced by the defects observed in these functions after the administration of CCK2 antagonists.

Original languageEnglish
Pages (from-to)690-698
Number of pages9
JournalNeuropsychopharmacology
Volume25
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Anxiety
  • CCK2 receptor-deficient mice
  • Memory
  • Motor activity
  • Neuromuscular deficits

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